Category: Platelet-Rich Plasma (PRP) Therapy

We are excited to share with you some early results from the global regenerative medicine research project that Integrated Orthopedics is participating in called Surgical Outcomes Systems (SOS). In most all cases, we are ahead or on par with global averages. Thank you to all of the patients who have participated in this study! Your participation is helping to build the evidence base for regenerative medicine in orthopedics which will eventually result, we believe, in this becoming a covered benefit by public and private insurance.

regenerative medicine, prp, platelet rich plasma therapy, stem cells, orthopedics, sports medicine



At the start of the New Year, many people decide to start a running program. We treat a lot of runners in our orthopedic and sports medicine practice and see a lot of the more common running injuries, with both new and long-time runners.

Running is a fantastic cardio workout, but if you’ve never run before – or are getting started again after an injury or break – it’s good to be aware of the more common running injuries.

Foot Mechanics & Running

During running, the foot is active in both the landing and push-off phase. It absorbs the shock of impact when landing and controls the forces generated by running during push-off. Most running injuries can be linked to one of these two functions.

Common Running Injuries

Here are the most common injuries runners experience and tips to prevent these injuries from occurring:

Plantar Fasciitis:
This is probably the most common running injury. It is usually due to overtraining, especially hill work and speed work; and not stretching the calf muscles. The plantar fascia – a think band of tissues that stretches from the toes to the heel – is prone to tearing when overworked. This tearing results in inflammation. The slow blood supply to the fascia hinders healing and results in a chronic condition.

To prevent plantar fasciitis, follow these tips:

  • Wear the right shows with good arch support and heel cushioning
  • Stretch the Achilles tendon regularly
  • Keep at a healthy weight
  • Increase your running gradually and alternate running with other activities
  • Try to minimize going barefoot at home which puts stress on the feet

Achilles Tendinitis:
This large strong tendon runs from the heel to the calf and propels you forward while running. Overworking the Achilles tendon results in inflammation.

A couple good ways to ward off Achilles tendinitis are:

  • Tennis ball roll: Loosen your plantar fascia by rolling a tennis ball under each foot. The muscles and tendons along the bottom of your foot exert pressure from below on the Achilles. This exercise helps keeps things loose.
  • Foam roller: You can increase the flexibility in your lower legs with a foam roller, rolling it over the front and back of the lower legs. This release tightness and tension.

Stress Fracture:
The most common runners’ stress fracture is to the tibia, or shin bone. This type of fracture occurs with issues related to the landing or push-off phase of running.

Here are a few tips to prevent shin fractures:

  • Do exercises to keep calf muscles healthy – do calf raises to strengthen them and stretches the loosen these muscles
  • Avoid muscle fatigue in the legs – when muscles fatigue, weight distribution shifts and the bone takes increased weight and impact
  • Don’t shift from soft trails to hard surfaces rapidly
  • Wear shoes with good shock absorbance

Runners Knee:
When the foot is not stable and lands in an uncontrolled way, runner’s knee can develop. It can also be caused by a biomechanical issue such as the patella being larger on the outside than it is on the inside, or a patella that easily dislocates. Worn cartilage in the knee joint also reduces shock absorption. High-arched feet can be a culprit as well as flat feet.

To prevent runner’s knee, follow these tips:

  • Run on soft surfaces
  • Do not increase mileage more than 10 percent per week
  • Gradually increase hill work
  • Go to a specialty running shoe store to get fitted for the proper shoes for your foot and gait
  • Incorporate exercises that strengthen the quadriceps muscles to improve patellar tracking
  • Stretch your hamstrings and calves to prevent over-pronation (too much inward rolling of the foot)

Our bodies change as we age – some subtle changes, some more obvious. However, many of us can remain active, healthy and vibrant throughout their lives.

In fact, our physiologic age can often be younger than our chronological age – often due to diet and lifestyle factors combined with our genetics.

Let’s look at the effects of aging on the muscles, bones and joints. Then, we’ll explore some ways to counteract the effects of aging on these parts of your body.

Aging Muscles:

  • Muscles shrink and lose mass as they age – this is a natural process. However, living a sedentary lifestyle accelerates the process.
  • Muscle fibers also decrease with age, making it take longer for our muscles to respond as we age.
  • Tissues get stiffer with age and less able to tolerate stress. This is due to the decrease in the water content of tendons.
  • The heart muscle is less able to propel large quantities of blood to the body and we tend to tire more easily as we age and recover less quickly.
  • Our metabolic rate – how quickly we convert food into energy – slows with age. The effects can be obesity and an increase in “bad” cholesterol levels.

Aging Bones:

  • During our lifetime, our bones are consistently going through a process of absorption and formation called “remodeling.” The balance between absorption and formation shifts with age, resulting in loss of bone tissue.
  • Bones become less dense with age as the mineral content decreases.
  • With loss of bone mass, common age-related conditions like osteoporosis can develop, a condition responsible for nearly all hip fractures in older men and women.
  • Arthritis can develop from loss of cartilage between the bones, which occurs with age.
  • As we age, our ligaments, connective tissue become less elastic and we lose flexibility.

Aging Joints:

  • Changes in tendons and ligaments with aging result in less joint flexibility and motion.
  • As cartilage breaks down with age – which cushions our joints – the joints can become inflamed and arthritic.

Slowing the Progression of Age-Related Orthopedic Conditions

Now that we’ve covered the effects of aging on the muscles, bones and joints, let’s look at ways to counterbalance them.

Disuse is often the biggest culprit in our musculoskeletal system’s aging.

And, guess what? The most sedentary group of Americans is older than 50. The right lifestyle choices will go a long way to combat aging on the musculoskeletal system.

  • Stretching – Regular stretching will help to maintain joint flexibility.
  • Weight Training – Increases your muscle mass and strength. Maintaining muscle mass will allow you to do your daily activities much easier with less exertion.
  • Aerobic Exercise – Studies show that just 30 minutes of moderate aerobic exercise a day can help maintain your body’s response time, deliver and use oxygen efficiently and keep your heart muscle strong.
  • Healthy Diet – You are what you eat, so make sure to load up on nutrient dense real foods and get adequate amounts of lean protein in your diet.

When the Effects of Aging Occur

The body does age even with all the right lifestyle choices. Its muscles, joints and bones will change with age. As an orthopedic surgeon, we work with many patients over 50-years-old to help them manage age-related orthopedic conditions and stay active. Sometimes surgery is needed, but more than not, non-invasive treatments can manage these conditions, including:

  • Regenerative Medicine (Platelet-Rich Plasma Therapy and Stem Cells)
  • Injection Therapy (Steroid and Hyaluronic Acid)
  • Physical Therapy

If you’re not hanging out with us over on Snapchat, take a quick look at this video our team produced. We hope this “sneak peek” entices you to come on over and join us on Snapchat each Tuesday and Thursday for an insider’s look into the OR and orthopedic surgery!

Snapchat: bfgorthodocaz — or click on the Snapchat icon in the upper-right corner of this website.

hip health, orthopedics

Maintaining joint health as we age is a priority for many active seniors, and understandably so. The most common conditions that affect the joints as we age include:

  • Hip osteoarthritis (Hip OA)
  • Trochanteric bursitis (inflammation of the bursa that lies next to the trochanteric bursae)
  • Osteonecrosis of the femoral head (death of bone tissue due to a lack of blood supply)

Fortunately, orthopedic medicine offers many options for healthy hips, and increasingly so with advances in regenerative medicine. 

Conventional Treatments

Let’s start with more conventional orthopedic options for hip health. The basics of maintaining and improving joint health – including the hips – starts with having an exercise program and maintaining a healthy weight.

Research consistently demonstrates that patients who lose weight, even at modest amounts, see reductions in their pain and disability. While there is more research to support the effects of weight loss on knee arthritis, weight loss is likely helpful for hip OA and other hip conditions as well. Exercise programs that include strength training, aerobics and range of motion exercises can help with both pain and physical function. Notably, strengthening exercises can help with hip OA.

In our clinic, we often use two types of conventional treatments for hip arthritis and hip conditions:

  • Corticosteroid Injections: Corticosteroid compounds injected directly into the affected joins can be useful for short-term pain reduction. Reoccurring injections can be utilized judiciously (2-3x per year) to maintain relief, although many patients and providers are cautious with long-term corticosteroid injection therapy.
  • Hyaluronic Acid Injections: Hyaluronic acid mimics the body’s natural substance that gives joint fluid its viscosity. Research shows that hyaluronic acid injections typically reach their peak effectiveness at around eight weeks after being given and last for about 24 weeks. The HA injections are excellent for knee arthritis. Unfortunately, these are considered off-label for the hip and not covered by insurance for this body part.

Medications and supplements that can help with mild-to-moderate hip OA include:

  • Acetaminophen (Tylenol) – Long-term use is a concern as to the risks of ulcers, GI bleeding and loss of kidney function for healthy individuals. For those with preexisting conditions such as diabetes, high blood pressure, cardiovascular disease, GI bleeding and kidney failure, this medication is likely unsuitable.
  • Nonsteroidal anti-inflammatory drugs (NSAIDS) – These drugs can an option for pain relief, but come with more risks than acetaminophen, typically, and should be used with caution. Those with cardiovascular disease or GI bleeding should likely avoid NSAIDS completely and others with certain pre-existing conditions should ask their doctor before using them even for short-term use.
  • Glucosamine – While scientific evidence has yet to fully support the use of glucosamine for joint health, some studies show it improves pain and physical discomfort in hip OA and may be worth a try.

Regenerative Medicine

Now, let’s turn to regenerative medicine, an increasingly evidence-based form of medicine that offers exciting new solutions for orthopedic patients.

Hip conditions with aging, including hip replacement surgery, are relatively common. While there are times when surgery is the best option, increasingly regenerative medicine offers a safe and effective treatment alternative to more conventional therapies. At minimum, it can buy time for patients on track for a total hip replacement. I’ve seen evidence of this many times over in my practice.

What is Regenerative Medicine?

When tissue such as muscle, tendon, ligament or cartilage is injured, the body tries to heal the injury through its own repair mechanism. However, in certain situations (especially in areas where there is lack of blood flow – such as inside and around the joints) the body can’t heal the injury adequately, if at all. With regenerative medicine, we aim to augment the natural healing process to heal or even “grow back” the damaged tissue.

Within orthopedics, there are two forms of regenerative medicine we practice:

Stem Cell Therapy – Stem cell-based therapies for the repair or regeneration of muscle and tendon represent a promising technology going forward for numerous diseases.1 A type of stem cell called mesenchymal stem cells (MSCs) have gained the most attention in the field of surgery due to their ability to differentiate into the tissues of interest for the surgeon.2  These multipotent stem cells in adults originate from mesenchymal tissues such as bone marrow, tendon, adipose (fat) and muscle tissue. In orthopedics, we primary harvest stem cells from the bone, notably the iliac crest of the pelvis. As stem cell therapy continues to emerge, we will eventually add adipose (fat) stem cell harvesting.

We conduct many stem cell procedures right in the clinic – as opposed to in the operating room, where it’s costlier to the patient and often less comfortable. We pre-medicate patients to make them as comfortable as possible. Then the pelvis – where the stem cells will be harvested from – is anesthetized. A special needle called a Jamshidi™ needle is used to harvest the bone marrow.

Platelet-Rich Plasma Therapy (PRP) – PRP involves the use of the platelets from blood, which is mainly a liquid composed of plasma, but also contains red cells, white cells and platelets. Platelets contain hundreds of proteins called growth factors, which are very important in healing injuries.

PRP is conducted in the clinic unless it is being used as an addition to a surgical procedure. It begins with a standard blood draw on a patient, where we draw 15 milliliters of blood. PRP is then prepared by separating the platelets from other blood cells and increasing their concentration in a process called centrifugation. This is done in a centrifuge device, and a trained representative from the device company is onsite to prepare the PRP. The PRP with its increased concentration of platelets is combined with the remaining blood and injected via guided ultrasound into the injured tissue. The use of ultrasound is important as it allows us to be very exacting in placing the PRP.

Benefits to Patients

Both forms of regenerative medicine are appealing to patients as they are minimally invasive and often performed in the clinic in a relaxed setting with little down time. Both stem cells and PRP can be performed as an adjunct to surgery to enhance its outcome or as a standalone procedure done right in the clinic.

A major advantage of regenerative medicine that is appealing to patients is that it leverages the natural healing process using the body’s own tissue. Additionally, the ease of preparation and administration; relative safety; and cost-effectiveness, as compared with surgical options are attractive to patients. Both forms of regenerative medicine can be used to treat some aging-related hip conditions and offer an exciting option for patients.

To learn more about Brian Gruber, MD, MBA, board certified orthopedic surgeon and his orthopedic and physical therapy practice, visit

  1. Oh JH, Chung SW, Kim SH, Chung JY, Kim JY. 2013 Neer Award: Effect of the Adipose-Derived Stem Cell for the Improvement of Fatty Degeneration and Rotator Cuff Healing in Rabbit Model. J Shoulder Elb Surg. 2014;23(4):445-455.
  2. Jang KM, Lim HC, Jung WY, Moon SW, Wang JH. Efficacy and Safety of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Anterior Cruciate Ligament Reconstruction of a Rabbit Model: New Strategy to Enhance Tendon Graft Healing. Arthroscopy.2015;31(8):1530-1539.


We hope to see you there! Be sure to RSVP as space is limited.

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At Integrated Orthopedics, we are committed to providing innovative, yet evidence-based orthopedic care. This is a good study on the use of platelet-rich plasma therapy (PRP) for treating chronic tennis elbow for patients who failed more conventional treatments.

At Integrated Orthopedics, we are dedicated to providing our patients with the most innovative and evidence-based therapies in orthopedic and sports medicine, including regenerative medicine/biologics. Check out this study on the use of bone marrow concentrate (BMAC) and platelet-rich plasma (PRP) for osteoarthritis.

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Janice Sullivan takes “animal lover” to a whole new level. As the owner of an RV park called Horspitality in Wickenburg, Arizona, she cares for four dogs, seven cats and one donkey on her property, where she resides with her husband Paul.

A bit more about the donkey, Bucky…

“Someone dumped him off starving and thirsty,” said Janice. “I noticed him among the cows, where I keep hay and water for the animals and then one day he was gone.”

Janice found Bucky under one of the RVs where she believes he’d gone to die.  With assistance from her staff and some applesauce, they lured him out from under the RV and got him standing up. They put Bucky in a pen, and over the course of two months, fed him and nursed him back to health.

Bucky is now the unofficial mascot of Horspitality!

As you can see, Janice is a vibrant woman who enjoys being with her animals and taking care of her guests at the RV park.

Janice also struggles with lupus, an autoimmune disease that affects her daily. A serious neck injury and associated surgery also left her with a lot of pain and discomfort in both her neck and shoulder. While these conditions affect her health and activities, she still enjoys her walks, cooking and interacting with her guests.

A Turning Point with Her Injuries

One night Janice woke up in unbearable pain like nothing she’d ever experienced before.

“It felt like I was being stabbed in my left shoulder blade and neck,” Janice shared. “I went to the hospital and had an MRI, which revealed that the plate in my neck had collapsed, fractured my neck and worked its way down to my shoulder.”

After recovering from the acute aspect of this injury, Janice continued to experience severe pain. “Not only was I still in a lot of pain, I had very limited use of my shoulder and arms,” said Janice.

She shared that she could do almost no daily activities, including washing her hair, brushing her teeth, reaching for a bar of soap, carrying a grocery bag, among others. She added that due to the pain, she could not sleep laying down or through the night and had to sleep sitting up.

Janice found Brian Gruber, MD, MBA, board certified orthopedic surgeon online through Facebook. She started watching his videos on YouTube, including one on platelet-rich plasma therapy (PRP), a form of orthobiologic regenerative medicine.

“I used to be an investigative paralegal,” said Janice. “I really did my homework on Dr. Gruber and liked what I found and saw, so decided to go see him for a second opinion.”

Janice had been told she’d need surgery, which she wanted to avoid. After discussing her case with Dr. Gruber, they decided to start with steroid shots and physical therapy. She saw some relief, but was still in pain.

Platelet-Rich Plasma Therapy (PRP) – A Return to Daily Activities

After learning more about Platelet-Rich Plasma Therapy (PRP) on her own, Janice asked Dr. Gruber about it. “We talked about it for a long time and he was very honest and told me the best and worst case scenarios,” said Janice.

Janice’s primary goal was pain relief. A bonus would have been more range of motion in her shoulder and a return to many daily activities she could no longer do, including caring for Bucky.

After four PRP injections, Janice is thrilled with her outcome. “The PRP more than exceeded my goals. Not only did I get pain relief, I am back to almost all my daily activities,” she said. “After two years of not driving, I am driving again and sleeping laying down and through the night without pain.”

Janice had a series of four PRP injections. She said she saw pain relief after the first injection, but the pain and mobility greatly increased after the third injection. By her fourth injection, she says she experienced “leaps and bounds” in her recovery.

“I felt like a kid,” Janice shared. “I can do so many of the things I had not been able to do for so long again and that we all take for granted.”

Janice has recommended Dr. Gruber and PRP to many of her guests at the RV park she runs with her husband, including a man from Missouri who is now back working his ranch after having PRP on his knee with Dr. Gruber.

“Dr. Gruber is a physician/scientist who keeps up with the science in his field,” said Janice. “He is so easy to talk to, jokes around with you, but is always incredibly professional.”

Janice added that the entire Integrated Orthopedics staff is wonderful. “You feel so welcomed when you visit there, and it’s definitely a team approach to care. The office is very professional, yet you feel like part of the family.”

Learn more about Platelet-Rich Plasma Therapy (PRP).